Rab5 is required for Caveolin-1-enhanced Rac1 activation, migration and invasion of metastatic cancer cells
نویسندگان
چکیده
Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago, Chile Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Santiago, Chile Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Universidad de Chile, Santiago, Chile Program of Cell and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile Moores UCSD Cancer Center, University of California, La Jolla, CA, USA
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Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential to promote migration. However, the role of caveolin-1 in migration of metastatic cells remains poorly defined. Here, caveolin-1 participation in metastatic cell migration w...
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